Week 13 in the NFL is well underway with four games already under our belts over the Thanksgiving and Black Friday holiday. Now, it's time to heat up the leftovers and gear up for a jam-packed Sunday slate where we have a number of key matchups with major playoff implications.

Before looking at SportsbookWire staff's Week 13 NFL picks, here are the against-the-spread (ATS) and Over/Under (O/U) leaders, according to Teamrankings.com. The Detroit Lions (10-1 straight up) head into their Thanksgiving home game vs.

One fascinating matchup to watch for is wideout Courtland Sutton against cornerback Denzel Ward. The latter leads football with 17 passes deflected. And Sutton is enjoying his best season since his 2019 Pro Bowl campaign. He’s capable of acrobatic, catch-of-the-year grabs on any drive.