This is the fifth time the Bills are playing in prime-time this year and they are 3-1, though the loss did come in their only ...

George Kittle will lead the San Francisco 49ers into their game versus the Buffalo Bills at Highmark Stadium on Sunday at ...

Simpson carried the ball 29 times against the Lions and set a new NFL record with 273 rushing yards, breaking his own record ...

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San Francisco 49ers defensive end Nick Bosa missed Wednesday's practice as the team began preparations for Sunday's game ...

Bills' QB Josh Allen is the current favorite for MVP. Expectations aren't something I like to make a habit. However, it's ...

While the 49ers look like an easy opponent, San Francisco's health could be a major factor in the game, warns one NFL expert.

The Bills and 49ers meet on Sunday Night Football in a game with playoff implications for both teams. Here are three ...

Josh Allen and the Buffalo Bills are coming off their bye week with a 9-2 record and a four game lead in the division.

Former Buffalo Bills (and current San Francisco 49ers) defender Leonard Floyd will be facing off against his old club this ...

The Lions’ last Thanksgiving win came in thrilling fashion. It was a defensive battle, as Detroit scored its only touchdown ...

Former Buffalo Bills quarterback Ryan Fitzpatrick recently sang the praises of current field general Josh Allen.