Background Severe asthma is a chronic lung disease characterised by inflammation, airway hyperresponsiveness (AHR) and airway remodelling. The molecular mechanisms underlying uncontrolled airway ...
Introduction Chronic rhinosinusitis with nasal polyposis (CRSwNP) affects a significant proportion of people with severe asthma (SA). Despite the effectiveness of anti-IL5/5R therapies in the ...
Correspondence to: Professor J A Wedzicha Royal Free and University College Medical School, London NW3 2PF, UK; j.a.wedzicha{at}medsch.ucl.ac.uk If you wish to reuse ...
Environmental factors, here taken to include pollutants, lifestyle factors and behaviours, can play an important role in serious, chronic pathologies with large societal and economic costs, including ...
8 Biometrics, Late-stage Development, Respiratory and Immunology, BioPharmaceuticals RandD, AstraZeneca, Cambridge, UK 9 Late-stage Development, Respiratory and ...
Background Idiopathic pulmonary fibrosis (IPF) is a disease of progressive lung scarring. There is a known association ...
Atypical radiological manifestation of sarcoidosis presenting with an anterior mediastinal mass ...
Background Patient perception of asthma treatment is rarely captured, and no specific tools exist to measure it. We developed an inhouse severe asthma patient feedback questionnaire (SAPFQ) using ...
Background Bronchoalveolar lavage (BAL) is essential in determining the efficacy of novel therapies in alpha-1 antitrypsin deficiency (AATD). These require initial proof-of-concept demonstration that ...
Background The evidence base on montelukast-associated adverse outcomes is inconclusive in children and young persons (CYP) with asthma. We aimed to investigate 1-year incidence of neuropsychiatric ...
Background Smoking and severe asthma exacerbations in pregnancy are risk factors for low birth weight babies. No studies have assessed the clinical implications of smoking on asthma exacerbations in ...
8 Department of Respiratory Medicine at Royal Brompton Hospital, London, Chelsea & Westminster Hospital, and Imperial College, London, UK 9 Chelsea and Westminster Hospital, London, UK Correspondence ...